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Geoffrey S. Gottlieb, MD, PhD

Ultimately, our goal is to help improve care and treatment for people infected with HIV-2

750 Republican St. Room E771 Seattle, WA 98109
(206) 616-2631

Research Team

Seattle Team:
Robert Smith
Dana Raugi
Noelle Benzekri
Jessica Micovic
Alex Montano
Mariah Oakes
Sally Leong
Senegal Team:
Moussa Seydi
Papa Salif Sow
Macoumba Toure
Selly Ba
Fatima Sall
Fatou Traore
Bintou Diaw
Alassane Niang
ElHadji Ibrahima Sall
Ousseynou Cisse
Jean Philippe Diatta
Raphael Bakhourn
Juliette Gomis
Geoffrey S. Gottlieb, MD, PhD
Associate Professor, Division of Allergy and Infectious Diseases, Department of Medicine Adjunct Associate Professor, Department of Global Health University of Washington

Dr. Gottlieb is the PI of a study in Senegal, West Africa on the effect of antiretroviral therapy (ART) on HIV-2 disease outcomes, emergence of drug resistance, and genital shedding. HIV-2 is intrinsically resistant to the non-nucleoside reverse transcriptase inhibitors (NNRTI), Fusion inhibitors (enfurvirtide), partially resistant to some protease inhibitors (PI) (and has a low genetic barrier to nucleoside reverse transcriptase inhibitors [NRTI] resistance), making treatment algorithms in resource-limited settings challenging.

Dr. Gottlieb is also involved in understanding the differences between the natural history, clinical, immunologic and virologic aspects of HIV-1 and HIV-2 infection. HIV-2 is generally less pathogenic than HIV-1. Compared to HIV-1, HIV-2 infection is characterized by a much longer asymptomatic stage, lower plasma viral loads, slower decline in CD4 count, lower mortality rate due to AIDS, lower rates of mother to child transmission and lower rates of sexual transmission. In addition, he has been studying the effects of dual infection with HIV-1 and HIV-2 on disease outcomes and ART in Senegal. This work is an ongoing collaborative effort between the UW and the University of Dakar, Senegal, since the early 1990's. Project opportunities include both Senegal field work (in Dakar and Ziguinchor) and Seattle based lab studies.

Dr. Gottlieb a collaborator with the IeDEA-West Africa network to study HIV-2 throughout West Africa as well as the ACHIEV2E Network to Study HIV-2 in North America and Europe.

Dr. Gottlieb is also a Co-investigator in a study to understand the occurrence and outcome of infection with more than one strain of HIV-1. Dual HIV-1 infection (both Co- and Super-infection) as been associated with higher viral loads, faster rate of CD4 decline, and more rapid progression to AIDS. The "Superinfection Project" is a collaborative effort, between Jim Mullins' group at the UW and the MACS cohort, to elucidate the virologic and host factors associated with infection with more than one strain of HIV-1.