Current methods for T cell antigen discovery are low throughput, failing to explore a board range of potential antigen-receptor interactions. Epitopes are the part of the antigen molecule to which an antibody attaches itself.
An effective vaccine must stimulate coordinated T cell responses and enlarging the scope and frequency of specific T cells are advantageous for identifying a candidate antigen. It is hoped novel methods will be applicable to many pathogens and the selection of T cell antigens for inclusion in candidate vaccines.
Sources: Journal of Clinical Investigation
CERID is working to develop and optimize high throughput techniques for genome-wide screening of candidate T cell antigens for vaccine development.