T cells play a central role in the immune system as effectors and regulators. They become activated upon antigen recognition by their T-cell receptors (TCR).
Failure of this system can lead to autoimmune disease. T cells are normally activated by signal transduction through the TCR/CD3 complex and accessory molecules such as CD4 and CD8.
Studies related to different functional aspects of TCR physiology contribute to the diagnosis and understanding of reactive and malignant T-cell disorders. This will eventually lead to new diagnostic concepts and novel therapeutic strategies.