Thomas R. Hawn, MD, PhD | Center for Emerging and Re-emerging Infectious Diseases

Professor

Department of Medicine, Division of Allergy and Infectious Diseases

Adjunct Professor

Department of Global Health

Co-Director, Center for Emerging and Re-emerging Infectious Diseases (CERID)

Faculty Information

Biography

Tom Hawn studies the functional and clinical significance of human variation in the innate immune system and its regulation of susceptibility to tuberculosis and other infections.

His laboratory defines and characterizes the cellular function of genetic polymorphisms in innate immune response genes and the mechanisms of how they regulate susceptibility to human infection with an overall goal of elucidating novel therapeutic strategies.

Education & Training:

Princeton University

Princeton NJ

1983-1987

American - Scandinavian Foundation Fellow

University of Stockholm

Stockholm, Sweden

1987-1988

Johns Hopkins University

Baltimore MD

1988-1995

PhD

Johns Hopkins University

Baltimore MD

1988-1995

Internship & Residency in Internal Medicine

University of Washington

Seattle WA

1995-1998

Fellowship in Infectious Diseases

University of Washington Medical Center

Seattle WA

1998-2001

Visiting Scientist

Institute for Systems Biology

Seattle WA

2000-2005

Honors:

UW Dept of Medicine ’s Philip and Helen Fialkow Award

2008

Burroughs Wellcome Fund Clinical Scientist Award in Translational Research

2009-2015

Elected into American Society of Clinical Investigation

2011

UW Department of Medicine Housestaff Research Mentorship Award

2013

Contact

Email:

thawn@uw.edu

Phone:

(206) 616-4124

Mailing Address:

750 Republican St. Box 358061 Seattle, WA 98109-4766

Research & Clinical Interests

Research Interests:

Current research projects include examination of the immune response to Mycobacteria. These studies are focused on understanding why individuals are resistant to M. tuberculosis infection, what regulates the response to vaccination, and studying why some individuals get more severe forms of tuberculosis (e.g. TB meningitis).

Projects involve examination of the human immune response with a mixture of genetic and cellular techniques to compare immune responses in different populations. Cellular studies include manipulation of gene expression with gene editing techniques and the study of innate immune responses to M. tuberculosis infection in monocytes and macrophages.

Publications

PubMed:

PubMed Bibliography

My NCBI:

My NCBI Bibliography

Publications:

Simmons JD, Stein CM, Seshadri C, Campo M, Alter G, Fortune S, Schurr E, Wallis RS, Churchyard G, Mayanja-Kizza H, Boom WH, Hawn TR (2018) Immunologic mechanisms of human resistance to persistent Mycobacterium tuberculosis infection. Nat Rev Immunol [Epub ahead of print]. PMID 29895826.

Shah, JA, Musvosi, M, Shey, M, Horne, DJ, Wells, RD, Peterson, GJ, Cox, JS, Daya, M, Hoal, EG, Lin, L, Gottardo, R, Hanekom, WA, Scriba, TJ, Hatherill, M, Hawn, TR (2017) A functional TOLLIP variant is associated with BCG-specific immune responses and tuberculosis. Amer. J. Resp. Care and Critical Medicine. 196: 502-511. PMID28463648.