Photo of Dr. Thomas Hawn
Professor
Department of Medicine, Division of Allergy and Infectious Diseases
Adjunct Professor
Department of Global Health
Co-Director, Center for Emerging and Re-emerging Infectious Diseases (CERID)

Faculty Information

Biography

Tom Hawn studies the functional and clinical significance of human variation in the innate immune system and its regulation of susceptibility to tuberculosis and other infections.

His laboratory defines and characterizes the cellular function of genetic polymorphisms in innate immune response genes and the mechanisms of how they regulate susceptibility to human infection with an overall goal of elucidating novel therapeutic strategies.

Education & Training: 
AB
Princeton University
Princeton NJ
1983-1987
American - Scandinavian Foundation Fellow
University of Stockholm
Stockholm, Sweden
1987-1988
MD
Johns Hopkins University
Baltimore MD
1988-1995
PhD
Johns Hopkins University
Baltimore MD
1988-1995
Internship & Residency in Internal Medicine
University of Washington
Seattle WA
1995-1998
Fellowship in Infectious Diseases
University of Washington Medical Center
Seattle WA
1998-2001
Visiting Scientist
Institute for Systems Biology
Seattle WA
2000-2005
Honors: 
UW Dept of Medicine ’s Philip and Helen Fialkow Award
2008
Burroughs Wellcome Fund Clinical Scientist Award in Translational Research
2009-2015
Elected into American Society of Clinical Investigation
2011
UW Department of Medicine Housestaff Research Mentorship Award
2013
Contact
Email: 
Phone: 
(206) 616-4124
Mailing Address: 

750 Republican St. Box 358061 Seattle, WA 98109-4766

Research & Clinical Interests
Research Interests: 

Current research projects include examination of the immune response to Mycobacteria. These studies are focused on understanding why individuals are resistant to M. tuberculosis infection, what regulates the response to vaccination, and studying why some individuals get more severe forms of tuberculosis (e.g. TB meningitis).

Projects involve examination of the human immune response with a mixture of genetic and cellular techniques to compare immune responses in different populations. Cellular studies include manipulation of gene expression with gene editing techniques and the study of innate immune responses to M. tuberculosis infection in monocytes and macrophages.

Publications
Publications: 

Simmons JD, Stein CM, Seshadri C, Campo M, Alter G, Fortune S, Schurr E, Wallis RS, Churchyard G, Mayanja-Kizza H, Boom WH, Hawn TR (2018) Immunologic mechanisms of human resistance to persistent Mycobacterium tuberculosis infection.  Nat Rev Immunol [Epub ahead of print]. PMID 29895826.

Shah, JA, Musvosi, M, Shey, M, Horne, DJ, Wells, RD, Peterson, GJ, Cox, JS, Daya, M, Hoal, EG, Lin, L, Gottardo, R, Hanekom, WA, Scriba, TJ, Hatherill, M, Hawn, TR (2017) A functional TOLLIP variant is associated with BCG-specific immune responses and tuberculosis.  Amer. J. Resp. Care and Critical Medicine.  196: 502-511.  PMID28463648.