The overall mission of the Liles Lab is to investigate clinical problems at the bench, in order to gain novel insights into disease pathogenesis and to develop novel therapeutic approaches to important clinical problems.
This laboratory focuses on the role of dysregulated host responses in the pathogenesis of infectious diseases of public health importance. A guiding principle is rapid translation of experimental insights and advances gained in the laboratory to the clinical bedside.
The role of innate immunity and inflammation in the development of effective acquired/adaptive immunity to infectious diseases is an emerging interest in the Liles Lab, as is prognostic host-derived biomarker discovery.
Research utilizes a variety of molecular and cellular biology technologies (e.g., transfection/transduction strategies, real-time PCR, siRNA technology, Western blot, ELISA, etc.), expression microarray technology, mesenchymal stem cell and adoptive cell transfer technology, cell culture, work with patient specimens, and clinically relevant mouse models of malaria, sepsis, and acute lung injury.