David Koelle, MD

Professor

Department of Medicine, Division of Allergy and Infectious Diseases

Adjunct Professor

Department of Global Health

Joint Professor

Laboratory Medicine, Department of Medicine

Affiliate Investigator, Fred Hutchinson Cancer Research Center

Faculty Information

Biography

My research interests are in the areas of virology and immunology, with spillover into diverse areas including viral oncogenesis, tumor immunotherapy, practical vaccinology issues such as adjuvants and delivery systems, and immune-mediated adverse drug reactions.

The core skill in my lab is the refined dissection of the human T-cell response to large-genome pathogens, with a newer focus on T-cell receptor expression and biology.

Our deepest experience is with HSV-1, HSV-2, and VZV, where our work has spanned from candidate vaccine discovery to pre-clinical models to immunogenicity testing for clinical trials.

Education & Training:

University of Washington

Seattle WA

1985

Residency

Tufts-New England Medical Center

Boston MA

1986-1988

Fellowship in Infectious Diseases

University of Washington

Seattle WA

1989-1992

Honors:

Phi Beta Kappa

1979

Alpha Omega Alpha

1984

Fellow, Infectious Diseases Society of America

2009

American Board of Internal Medicine, Infectious Diseases

2013

Contact

Email:

DKoelle@medicine.washington.edu [2]

Phone:

(206) 616-1940

Mailing Address:

750 Republican Street, Room E651, Box 358061, Seattle, WA 98109

Research & Clinical Interests

Research Interests:

Vaccines with an emphasis on HSV and VZV
T cell homing
Tissue resident memory T cells
T cell receptor repertoire, sequencing and expression
Oncogenic polyomaviruses

Clinical Interests:

T cell testing for tuberculosis infection
HIV infection
Pathogen-related malignancies

Publications

PubMed:

PubMed Bibliography [3]

Publications:

Nayak K, Jing L, Russell RM, Davies DH, Hermanson G, Molina DM, Liang X, Sherman DR, Kwok WW, Yang J, Kenneth J, Ahamed SF, Chandele A, Kaja M-K, Koelle DM. 2015. Identification of novel Mycobacterium tuberculosis CD4 T-cell antigens via high throughput proteome scanning. Tuberculosis, ePub March 26, 2015. PMCI:D 25857935.

Laing KJ, Russell RM, Dong L, Schmid DS, Stern M, Magaret A, Haas J, Johnston C, Wald A, Koelle DM. 2015. Zoster vaccination increases the breadth of CD4+ T-cell responses to varicella zoster virus. Journal of Infectious Diseases, ePub March 17, 2015. PMCID: 25784732.

Chapuis AG, Afanasiev O, Iyer J, Paulson KG, Parvathaneni U, Hwang JH, Lai I, Roberts IM, Sloan HL, Bhatia S, Shibuya K, Gooley T, Desmarais C, Koelle DM., Yee C, Nghiem P. 2014. Regression of metastatic Merkel cell carcinoma following transfer of polyoma-specific T-cells and therapies capable of re-inducing HLA class. Cancer Immunology Research 2: 27-36. PMID: 24432305.