David

Koelle

MD

Biography

My research interests are in the areas of virology and immunology, with spillover into diverse areas including viral oncogenesis, tumor immunotherapy, practical vaccinology issues such as adjuvants and delivery systems, and immune-mediated adverse drug reactions.

The core skill in my lab is the refined dissection of the human T-cell response to large-genome pathogens, with a newer focus on T-cell receptor expression and biology.

Our deepest experience is with HSV-1, HSV-2, and VZV, where our work has spanned from candidate vaccine discovery to pre-clinical models to immunogenicity testing for clinical trials.

Education & Training: 

MD, University of Washington, Seattle WA (1985)

Residency, Tufts-New England Medical Center, Boston MA (1986-1988)

Fellowship in Infectious Diseases, University of Washington, Seattle WA (1989-1992)

Honors: 

Phi Beta Kappa (1979)

Alpha Omega Alpha (1984)

Fellow, Infectious Diseases Society of America (2009)

American Board of Internal Medicine, Infectious Diseases (2013)

Research Interests: 

• Vaccines with an emphasis on HSV and VZV
• T cell homing
• Tissue resident memory T cells
• T cell receptor repertoire, sequencing and expression
• Oncogenic polyomaviruses

Clinical Interests: 

• T cell testing for tuberculosis infection
• HIV infection
• Pathogen-related malignancies

Related Links

Publications 

Nayak K, Jing L, Russell RM, Davies DH, Hermanson G, Molina DM, Liang X, Sherman DR, Kwok WW, Yang J, Kenneth J, Ahamed SF, Chandele A, Kaja M-K, Koelle DM.  2015.  Identification of novel Mycobacterium tuberculosis CD4 T-cell antigens via high throughput proteome scanning.  Tuberculosis, ePub March 26, 2015. PMCI:D 25857935.

Laing KJ, Russell RM, Dong L, Schmid DS, Stern M, Magaret A, Haas J, Johnston C, Wald A, Koelle DM.  2015.  Zoster vaccination increases the breadth of CD4+ T-cell responses to varicella zoster virus.  Journal of Infectious Diseases, ePub March 17, 2015. PMCID: 25784732.

Chapuis AG, Afanasiev O, Iyer J, Paulson KG, Parvathaneni U, Hwang JH, Lai I, Roberts IM, Sloan HL, Bhatia S, Shibuya K, Gooley T, Desmarais C, Koelle DM., Yee C, Nghiem P. 2014. Regression of metastatic Merkel cell carcinoma following transfer of polyoma-specific T-cells and therapies capable of re-inducing HLA class. Cancer Immunology Research 2: 27-36. PMID: 24432305.